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Triptorelin
Data klinis
Nama dagang	Decapeptyl, Pamorelin, dll
AHFS/Drugs.com	Micromedex Detailed Consumer Information
License data	US DailyMed: Triptorelin;
Rute; pemberian	Intramuskular
Kelas obat	GnRH analogue; GnRH agonist; Antigonadotropin
Kode ATC	L02AE04 (WHO) QH01CA97;
Status hukum
Status hukum	AU: S4 (Prescription only) ; CA: ℞-only ; US: ℞-only ; ℞ (Hanya resep);
Data farmakokinetika
Ekskresi	Ginjal
Pengenal
	Nama IUPAC 5-oxo-D-prolyl-L-histidyl-Ltryptophyl-L-seryl-Ltyrosyl-3-(1H-indol-2-yl)-L-alanylleucyl-L-arginyl-L-prolylglycinamide;
Nomor CAS	57773-63-4 ;
PubChem CID	25074470;
IUPHAR/BPS	1177;
DrugBank	DB06825 ;
ChemSpider	17290424 ;
UNII	9081Y98W2V;
KEGG	D06247 ; D08649;
ChEBI	CHEBI:63633 ;
ChEMBL	ChEMBL1201334 ;
CompTox Dashboard (EPA)	DTXSID2048375 ;
ECHA InfoCard	100.165.044
Data sifat kimia dan fisik
Rumus	C64H82N18O13
Massa molar	1.311,47 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
	SMILES CC(C)C[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)[C@@H](Cc2c[nH]c3c2cccc3)NC(=O)[C@H](Cc4ccc(cc4)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc5c[nH]c6c5cccc6)NC(=O)[C@H](Cc7cnc[nH]7)NC(=O)[C@@H]8CCC(=O)N8;
	InChI InChI=1S/C64H82N18O13/c1-34(2)23-46(56(88)75-45(13-7-21-69-64(66)67)63(95)82-22-8-14-52(82)62(94)72-31-53(65)85)76-58(90)48(25-36-28-70-42-11-5-3-9-40(36)42)78-57(89)47(24-35-15-17-39(84)18-16-35)77-61(93)51(32-83)81-59(91)49(26-37-29-71-43-12-6-4-10-41(37)43)79-60(92)50(27-38-30-68-33-73-38)80-55(87)44-19-20-54(86)74-44/h3-6,9-12,15-18,28-30,33-34,44-52,70-71,83-84H,7-8,13-14,19-27,31-32H2,1-2H3,(H2,65,85)(H,68,73)(H,72,94)(H,74,86)(H,75,88)(H,76,90)(H,77,93)(H,78,89)(H,79,92)(H,80,87)(H,81,91)(H4,66,67,69)/t44-,45-,46-,47-,48+,49-,50-,51-,52-/m0/s1 ; Key:VXKHXGOKWPXYNA-PGBVPBMZSA-N ;
	(what is this?) (verify)

Triptorelin adalah hormon buatan yang dapat merangsang produksi hormon tertentu secara berlebihan, sehingga menyebabkan produksi hormon berhenti sementara. Triptorelin biasanya digunakan untuk mengobati gejala kanker prostat. Triptorelin hanya bisa mengatasi gejala kanker prostat, tetapi tidak mengobati kanker itu sendiri.^[3]^[4]

Obat ini dipatenkan pada 1975 dan disetujui untuk pemakaian medis pada 1986.^[5]

Referensi

^ "Prescription medicines: registration of new chemical entities in Australia, 2015". Therapeutic Goods Administration (TGA). 21 June 2022. Diakses tanggal 10 April 2023.
^ "Triptodur- triptorelin kit". DailyMed. U.S. National Library of Medicine. 28 April 2022. Diakses tanggal 15 May 2022.
^ "gonadorelin analogue | Encyclopedia.com". www.encyclopedia.com. Diakses tanggal 2019-09-21.
^ Joint Formulary Committee (2018). British National Formulary (BNF) 70. London: Pharmaceutical Press. hlm. 635. ISBN 978-0-85711-173-9.
^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (dalam bahasa Inggris). John Wiley & Sons. hlm. 514. ISBN 9783527607495.

Bacaan tambahan

Lahlou N, Carel JC, Chaussain JL, Roger M (July 2000). "Pharmacokinetics and pharmacodynamics of GnRH agonists: clinical implications in pediatrics". J Pediatr Endocrinol Metab. 13 Suppl 1: 723–37. doi:10.1515/jpem.2000.13.s1.723. PMID 10969915. S2CID 3639804.
Padula AM (August 2005). "GnRH analogues—agonists and antagonists". Anim Reprod Sci. 88 (1–2): 115–26. doi:10.1016/j.anireprosci.2005.05.005. PMID 15955640.

[1] "Prescription medicines: registration of new chemical entities in Australia, 2015". Therapeutic Goods Administration (TGA). 21 June 2022. Diakses tanggal 10 April 2023.

[2] "Triptodur- triptorelin kit". DailyMed. U.S. National Library of Medicine. 28 April 2022. Diakses tanggal 15 May 2022.

[encyclopedia.com-3] "gonadorelin analogue | Encyclopedia.com". www.encyclopedia.com. Diakses tanggal 2019-09-21.

[:0-4] Joint Formulary Committee (2018). British National Formulary (BNF) 70. London: Pharmaceutical Press. hlm. 635. ISBN 978-0-85711-173-9.

[Fis2006-5] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (dalam bahasa Inggris). John Wiley & Sons. hlm. 514. ISBN 9783527607495.

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Triptorelin

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