Ensiklopedia Dunia

Ilaprazol
Data klinis
Nama dagang	Lylian, Noltec
Rute; pemberian	Oral
Kode ATC	A02BC11 (WHO) ;
Pengenal
	Nama IUPAC 2-[(RS)-[(4-metoksi-3-metilpiridin-2-il)metil]sulfinil]-5-(1H-pirol-1-il)-1H-benzimidazola;
Nomor CAS	172152-36-2;
PubChem CID	214351;
ChemSpider	185839;
UNII	776Q6XX45J;
KEGG	D13013;
ChEMBL	ChEMBL2106370;
CompTox Dashboard (EPA)	DTXSID10870115 ;
Data sifat kimia dan fisik
Rumus	C19H18N4O2S
Massa molar	366,44 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
	SMILES Cc1c(OC)ccnc1CS(=O)c2[nH]c3ccc(cc3n2)n4cccc4;
	InChI InChI=1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22); Key:HRRXCXABAPSOCP-UHFFFAOYSA-N;

Ilaprazol (nama dagang Noltec) adalah penghambat pompa proton (PPI) yang digunakan dalam pengobatan dispepsia, penyakit tukak lambung (PUD), penyakit refluks gastroesofagus (GORD/GERD)^[1] dan tukak duodenum.^[2]^[3]

Obat ini tersedia dalam kekuatan 5, 10, dan 20 mg.

Studi klinis menunjukkan bahwa ilaprazol setidaknya merupakan PPI yang sama kuatnya dengan omeprazol jika dikonsumsi dalam dosis yang setara. Studi juga menunjukkan bahwa ilaprazol secara signifikan mencegah perkembangan esofagitis refluks.

Ilaprazol dikembangkan oleh Il-Yang Pharmaceutical (Korea), dan masih dalam uji klinis dengan FDA AS. Obat ini telah diluncurkan di Korea dan Cina untuk pengobatan tukak lambung, tukak duodenum, penyakit refluks gastroesofagus]], dan esofagitis erosif.^[4]

Referensi

^ Savarino E, Ottonello A, Martinucci I, Dulbecco P, Savarino V (October 2016). "Ilaprazole for the treatment of gastro-esophageal reflux". Expert Opinion on Pharmacotherapy. 17 (15): 2107–13. doi:10.1080/14656566.2016.1232389. PMID 27598861. S2CID 38638311.
^ Bohidar NP, Krishna K, Panda BK, Patel C (2013). "Ilaprazole: Is this a superior proton pump inhibitor for duodenal ulcer?". Tropical Gastroenterology. 34 (2): 95–8. doi:10.7869/tg.2012.105. PMID 24377157.
^ Ji XQ, Du JF, Chen G, Chen G, Yu B (May 2014). "Efficacy of ilaprazole in the treatment of duodenal ulcers: a meta-analysis". World Journal of Gastroenterology. 20 (17): 5119–23. doi:10.3748/wjg.v20.i17.5119. PMC 4009550. PMID 24803828.
^ Nomor uji klinis NCT00952978 for "Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients (Phase 3)" di ClinicalTrials.gov

[Savarino_2016-1] Savarino E, Ottonello A, Martinucci I, Dulbecco P, Savarino V (October 2016). "Ilaprazole for the treatment of gastro-esophageal reflux". Expert Opinion on Pharmacotherapy. 17 (15): 2107–13. doi:10.1080/14656566.2016.1232389. PMID 27598861. S2CID 38638311.

[Bohidar_2013-2] Bohidar NP, Krishna K, Panda BK, Patel C (2013). "Ilaprazole: Is this a superior proton pump inhibitor for duodenal ulcer?". Tropical Gastroenterology. 34 (2): 95–8. doi:10.7869/tg.2012.105. PMID 24377157.

[Ji_2014-3] Ji XQ, Du JF, Chen G, Chen G, Yu B (May 2014). "Efficacy of ilaprazole in the treatment of duodenal ulcers: a meta-analysis". World Journal of Gastroenterology. 20 (17): 5119–23. doi:10.3748/wjg.v20.i17.5119. PMC 4009550. PMID 24803828.

[NCT00952978-4] Nomor uji klinis NCT00952978 for "Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients (Phase 3)" di ClinicalTrials.gov

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Ensiklopedia Dunia

Ilaprazol

Referensi

Beranda

Program Studi

Data klinis

Nama dagang	Lylian, Noltec
Rute pemberian	Oral
Kode ATC	A02BC11 (WHO)
Pengenal
Nama IUPAC 2-[(RS)-[(4-metoksi-3-metilpiridin-2-il)metil]sulfinil]-5-(1H-pirol-1-il)-1H-benzimidazola
Nomor CAS	172152-36-2
PubChem CID	214351
ChemSpider	185839
UNII	776Q6XX45J
KEGG	D13013
ChEMBL	ChEMBL2106370
CompTox Dashboard (EPA)	DTXSID10870115
Data sifat kimia dan fisik
Rumus	C₁₉H₁₈N₄O₂S
Massa molar	366,44 g·mol⁻¹
Model 3D (JSmol)	Gambar interaktif
SMILES Cc1c(OC)ccnc1CS(=O)c2[nH]c3ccc(cc3n2)n4cccc4
InChI InChI=1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22) Key:HRRXCXABAPSOCP-UHFFFAOYSA-N